Nanostructured Lipid Carriers (NLC) for Parenteral Delivery of an Anticancer Drug

Nanostructured Lipid Drug Carriers

solid lipid carriers – NLC. Particulate lipid matrices in the form of lipid pellets are known from the textbooks since many years, products are on the market (e. g. Mucosolvan retard, Boehringer-Ingelheim). After these lipid pellets as the first generation, P. Speiser developed so-called “lipid nanopellets for oral administration” in the middle of the eighties [1]. This system was not further d...

Nanostructured lipid carriers: Promising drug delivery systems for future clinics.

During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administ...

Itraconazol-Loaded Nanostructured Lipid Carriers (NLC) for Pulmonary Application

Design and in vivo pharmacodynamic evaluation of nanostructured lipid carriers for parenteral delivery of artemether: Nanoject.

The objective of the present investigation was to explore the potential of nanostructured lipid carriers (NLC) for the intravenous delivery of artemether (ARM), a poorly water-soluble antimalarial agent. The NLC of ARM (Nanoject) were formulated by employing a microemulsion template technique. The NLC were evaluated for particle size, encapsulation efficiency, in vitro drug release and in vitro...

Nanostructured lipid carriers: versatile oral delivery vehicle

Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therape...